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Clinical Pharmacology
Objectives:To evaluate the efficacy and safety of a long-acting (LAS) quetiapine formulation in the treatment of acute depressive episodes. The efficacy and safety of LAS quetiapine in the treatment of acute depressive episodes, according to the Clinical Global Impressions Scale (CGI-I), as measured by the Montgomery-Asberg Depression Rating Scale (MADRS) and the Hamilton Rating Scale for Depression (H Rating Depression), have not been assessed.
Design/Principal Findings:The primary endpoint of the study was the change in MADRS score from baseline to 6 months. For the primary endpoint, the percentage of patients who reported a change in the MADRS score from baseline to the last follow-up (baseline value at 6 months), and for the secondary endpoints, the percentage of patients who reported a change from baseline to the last follow-up (baseline value at 6 months), were compared using the intention to treat (ITT) and the difference in the MADRS score by week 6 (baseline value at 6 months).
Conclusions:In this large open-label, randomized study, the LAS quetiapine formulation was more effective than monotherapy in the treatment of acute depressive episodes. It is important to note that this long-acting formulation may be more effective in patients with bipolar depression or other risk factors for bipolar depression.
Abbreviations:Bipolar I disorder, Bipolar II disorder, IRI, IIQ disorder, MADRS-R, Montgomery-Asberg Depression Rating Scale, HRSD, H Rating Depression, HRSN, Hamilton Rating Scale for Depression, IPD, IPR, IPR+, HRI, HRS, HRS/QRS, HRS/QRS, QRSD, QRS/QT axis,seroquel, QT/torsion. The content contained in this publication is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always consult with your physician or other qualified health care provider before starting, changing, or stopping any medication.
This report is part of a larger study of the efficacy and safety of long-acting quetiapine formulations in the treatment of acute depressive episodes.
Click to skip this articleQuetiapine, also known as quetiapine, is a selective serotonin reuptake inhibitor (SSRI) that works by increasing levels of serotonin in the brain. Serotonin is a neurotransmitter, and it is believed that its effect is beneficial for mood stabilization and for alleviating symptoms of depression, such as mood swings, anxiety, and insomnia. In this study, the efficacy and safety of quetiapine in the treatment of acute depressive episodes according to the Clinical Global Impressions Scale (CGI-I) and the Montgomery-Asberg Depression Rating Scale (MADRS) have not been evaluated.
This multicenter, double-blind, randomized, placebo-controlled, double-dosing study was conducted in Spain between September 2008 and June 2010.
Seroquel, branded to treat bipolar disorder, is a unique and effective treatment option for individuals struggling with the challenges of mental health conditions such as schizophrenia and depression. Seroquel works by increasing the levels of certain chemicals in the brain that are associated with mood and mental well-being. Developed by pharmaceutical company Lilly, Seroquel belongs to a class of medications known as atypical antipsychotics.
It works by blocking the action of certain natural chemicals in the brain that can affect mood, emotions, and other bodily functions. Seroquel is known for its effectiveness in managing conditions such as schizophrenia and bipolar disorder.
Manufactured by Lilly, Seroquel belongs to a class of medications known as atypical antipsychotics.
Seroquel works by increasing the levels of certain chemicals in the brain that can affect mood, emotions, and other bodily functions. It binds to certain receptors and affects specific neurotransmitters in the brain. This can lead to changes in mood, emotions, sleep patterns, and other bodily functions.
It works by increasing the levels of certain chemicals in the brain that can affect mood, emotions, and other bodily functions.
Seroquel® Tabletsare an anti-psychotic medication commonly used to treat major depressive disorder. These tablets work by helping the brain to increase the levels of serotonin and dopamine. Seroquel works by increasing the levels of these chemicals in the brain. Seroquel works by reducing symptoms of depression, such as feelings of sadness, loss of interest, and restlessness. It's important to note that not everyone experiences the same level of depression, and the medication may not work for everyone. This medication can have side effects such as dizziness, nausea, headache, and constipation. It is recommended to start taking Seroquel within the first couple of weeks of starting treatment and then decrease to the lowest effective dose for the shortest possible time. It's important to note that Seroquel may have a greater risk of side effects. It is generally safe to take Seroquel with or without food. However, it is important to follow your doctor's instructions and consult with your doctor if you experience any unusual symptoms.
Seroquel® Tablet Dosage:Seroquel tablets are available in a 50mg dose and can be taken with or without food. It is important to take the tablets at the same time every day to maintain consistent levels of the medication in your bloodstream. It is important to complete the full course of the medication even if you feel better, even if you start to feel better. It is recommended to take Seroquel approximately one hour before engaging in sexual activity. This may help to decrease sexual side effects. It's essential to complete the full course of the medication even if you feel better, even if you start to feel better. It is recommended to continue taking the medication for the full prescribed length of time. Do not stop taking Seroquel abruptly.
Seroquel® Tablet Precautions:Seroquel is not recommended to be taken with alcohol or other drugs. It's important to consult with your doctor before taking any other medications to avoid any potential drug interactions. Seroquel should not be used in individuals with a known hypersensitivity to any of its components.
Seroquel (quetiapine) is a type of prescription medication called an antipsychotic drug. These medications often treat conditions that can cause psychosis or losing touch with reality, but they also help with different kinds of depression and anxiety—especially when first-line treatments aren’t enough.
There are two types of antipsychotic drugs. “Typical” antipsychotics refer to the first generation of these drugs, which were developed in the 1950s. “Atypical” antipsychotics, which were introduced in the 1990s, are considered second-generation drugs. They are just as effective as typical antipsychotics but are much less likely to cause complications such as movement and motor control problems.
Seroquel (quetiapine) is an atypical antipsychotic. It changes how certain chemicals (dopamine and serotonin) work in the brain.
Dopamine is a “chemical messenger” (neurotransmitter) that delivers instructions to nerve cells in the brain. It helps control mood, pleasure, motivation, memory, attention, and other functions. Serotonin is also a chemical messenger. It’s sometimes called the feel-good chemical because it helps regulate your mood and sense of well-being.
In people with depression or psychosis, dopamine and serotonin signals don’t work properly. Seroquel (quetiapine) works by blocking these abnormal signals.
Typical antipsychotics:Seroquel (quetiapine) also isn’t approved as an initial type of antipsychotic. An antipsychotic drug is a type of medication called a drug that changes how a drug works or reduces how it works.
If a person has psychosis, they may lose their sense of smell or hearing. If they have depression, they may lose interest in usual activities or classes of work. They might have trouble sleeping or have trouble eating or sleeping. They might have suicidal thoughts or hallucinations or thoughts of self-harm or self-injury. They might have trouble concentrating or have problems speaking or thinking. They might have trouble thinking clearly or they might have trouble thinking independently.
CyclineCyclen (trazepatide) is a specific type of antipsychotic called a second-generation agent. It’s not an antipsychotic. It works by changing the amount of neurotransmitters in the brain. This means it changes how a person thinks and behaves.
CyclothoridazineCyclothoridazine also isn’t approved as an antipsychotic. An antipsychotic drug, it works by blocking at least a small part of the effects of dopamine and serotonin in the brain. This means they don’t have to work that way.
An antipsychotic drug may also lower levels of brain-transmitters such as norepinephrine and dopamine, which are neurotransmitters that help regulate mood, thoughts, and behavior. These neurotransmitters can help change how a person thinks and acts.
An antipsychotic drug may also improve symptoms of psychosis such as hallucinations, delusions, confusion, organization, and ease of thinking. It also may decrease the frequency and severity of hallucinations (such as a piercing sensation in the ears, a piercing sensation in the lungs, a whistling tre sense in the groin, a whistling tre sensation in the neck, a whistling tre sensation in the upper body, a whistling tre sensation in the upper body, a whistling tre sensation in the upper body, a very whistling tre sensation in the upper body, a very whistling tre sensation in the upper body, and a very very very very very very very very very very very very poor impulse or disorganized thinking).
Diphenhydramine also may improve symptoms of psychosis such as hallucinations, delusions, and confusion.